Naqshadaynta alaabta ceeriin ee cusub

Isku-ururinta molecular

--Kimistari cagaaran oo xuduud ah oo aan curaarta jebin iyo dib u xidhidh

Mabda'a asaasiga ah ee isku-ururinta molecular:

1. Sida soo jiidashada sida - wadista walxaha la midka ah si ay isu ururiyaan oo isu habeeyaan, iyo walxaha leh sifooyin dhammaystiran si ay isu soo jiitaan.

2. Tamarta ugu hooseysa—dhaqdhaqaaqa maaddooyinka iyo hab-dhaqanka molecular waxa ay u eegi doonaan xaaladda ugu xasilloon. Waa hab loogu talagalay kooxaha molecular in loo habeeyo qaab dhismeed horumarsan.

Naqshadeynta molecular-is-ururinta, qaab-dhismeedka CP ee u dhexeeya molecules wuxuu si weyn u wanaajin karaa dhaqdhaqaaqa noolaha:

1. Molecule kastaa waxa uu leeyahay qaab dhismeedkiisa gaarka ah iyo sifooyinkiisa shaqo, wayna adagtahay in la gaadho isku-dhafka iyo daawaynta saxda ah ee ku salaysan isku darka bilaashka ah ee heerka habaynta.

2. Weli waxaa jira unugyo badan oo leh firfircooni bayooloji oo aad u wanaagsan kuwaas oo si ba'an u xaddiday nuuggooda iyo isticmaalkooda sababo la xiriira astaamo xun.

3. Walxaha firfircoon ee daawada dhaqameed ee Shiinaha ayaa aad u gaar ah oo ku saabsan "boqortooyada, wasiirrada iyo kaaliyeyaasha", halkii ay ka ahaan lahaayeen hodgepodge oo ka sii wanaagsan.

Qaabka wax ka beddelka qaabdhismeedka sare iyo qaabka habraaca falanqaynta tayaynta:

1. Kombuyuutar-ku-caawiyey baadhis-qaadid sare oo loogu talagalay baadhista degdegga ah ee hor-u-yaasha ku habboon ee Xarunta Xogta ee Cambridge Crystal.

2. Isticmaal aragtida shaqaynta cufnaanta si aad u barato qaab dhismeedka supramolecular iyo guryaha isu-ururinta ee ay go'aamiyaan xoogagga intermolecular, oo go'aamiyo nooca supramolecular waa isbeddelka samaynta.

3. Iyadoo la falanqeynayo xaaladaha falcelinta iyo dhibka, qaabka supramolecular ayaa la hagaajiyay.

4. Xisaabinta sifooyinka kala duwan ee supramolecules, oo ay ku jiraan guryaha korantada, indhaha iyo heerkulbeegga.

5. Xisaabinta sifooyinka spectral sida spectrum molecular iyo spectrum tamarta.

6.Through technology docking molecular, goobaha isdhexgalka u dhexeeya alaabta ceeriin supramolecular iyo borotiinada bartilmaameedka ayaa la saadaaliyay, iyo habka is dhexgalka u dhexeeya molecules ayaa si qoto dheer loo qeexay.

Tignoolajiyada cusbada ee supramolecular eutectic/Ionic

Tilmaamaha farsamada: warshadaha ugu horreeya, baaritaanka qaybaha ugu wanaagsan ee CP ee qaybaha firfircoon ee xoojinta eutectic

Faa'iidooyinka: yaraynta xanaaqa, xoojiso milanka, wanaajiso shaqeynta, kor u qaadida qulqulka, hagaajinta xasiloonida

Tusaalooyinka maaddooyinka: salicylic acid, uric acid, ferulic acid, glycyrrhizic acid, adenosine, niacinamide, 4MSK

Maaddooyinka firfircoon ee dabiiciga ah ee laga soo qaatay buug-gacmeedka alaabta ceeriin ee la isku qurxiyo, ka dib tijaabooyinka xaqiijinta sida jilitaanka kiimikada quantum, baarista sare-u-qaadista, hagaajinta Gaussian, KingDraw, MestReNova, FTIR, iyo NMR, alaabada la helay waxay leeyihiin qaab dhismeed saddex-cabbir ah oo heer sare ah, xasillooni wanaagsan, nadiif sare, wasakh yar. Waxay si wax ku ool ah u xallin kartaa dhibcaha xanuunka codsiga ee maaddooyinka waxtarka leh ee cuntada, daawada iyo qurxinta, iyo hagaajinta bioavailability iyo badbaadada maaddooyinka shaqeynaya.

Farsamaynta soo saarista dhaqdhaqaaqa sare ee dhaqdhaqaaqa

Tilmaamaha farsamada: Warshadaha ugu horreeya, isku dhafka tignoolajiyada daabacaadda molecular iyo dareerayaasha dabiiciga ah ee supramolecular, soo saarista hufan ee maaddooyinka firfircoon ee dhirta

Faa'iidooyinka: Soo saarista la beegsanayo, waxtarka soo saarista ayaa kordhay 5 jeer marka la barbardhigo khamriga, soo saarista biyaha ayaa kordhay 20 jeer; kala sooc la'aan, kharash dhimis, maaddooyinka kor u qaada Tusaalooyinka: saytuunka (oleuropein, hydroxytyrosol), rhodiola, Phyloporus daawo, ubax cad oo biyo ah, micrococcus

Dabiiciga ah millatariga qoto dheer ee eutectic (NaDES): Waxaa markii ugu horreysay helay saynisyahano falanqaynta metabolomics dhirta. Inta lagu jiro marxaladaha koritaan ee dhirta qaarkood (biqilka, cryopreservation), unugyadu waxay si kedis ah u samaysan doonaan dareere aad u muuqda oo ka madax bannaan biyaha iyo dufanka, oo la mid ah isku dhafka eutectics.

Iyada oo ku saleysan tiknoolajiyada kala-soocidda cagaaran ee casriga ah, tignoolajiyada xuubka isku dhafan, oo lagu kabo tiknoolajiyada kor u qaadista ultrasonic / microwave si loo gaaro heerkul hoose, bartilmaameedsan, heer sare ah, tayo sare leh iyo soosaar cagaaran oo ka mid ah qaybaha firfircoon Walxaha supramolecular ee la doortay ayaa leh waxqabadka xasilloon iyo la xoojiyey ee maaddooyinka firfircoon, sidoo kale waxtarka soo saarista waxaa lagu kordhin karaa 20 jeer.

Tignoolajiyada galitaanka isku dhafka supramolecular

Tilmaamaha farsamada: Warshadaha ugu horreeya, iyada oo loo marayo dareeraha supramolecular synergistically kor u dhexgalka ee macromolecules/biyaha-milmay/ adag tahay in la nuugo maaddooyinka

Faa'iidooyinka farsamada: hagaajinta xasiloonida, horumarinta wax-ku-oolka aan burburin iyo waxtarka leh, saameynta isku-dhafka ah, kobcinta jihada ee maqaarka, iyo bioavailability ayaa kordhay 5-7 jeer Tusaalooyinka Maaddada: kolajka, Bosein, peptide buluug buluug ah, hexapeptide, peptide compound, β-glucan.

Maadaama miisaanka molecular ee peptide uu weli yahay mid aad u weyn marka loo eego maaddooyinka kale ee firfircoon, dhexgalka maqaarku waa mid hooseeya. Qaar ka mid ah hababka kor u qaadida dhexgalka ayaa loo baahan yahay si loo hagaajiyo dhexgalka-kor u qaada saamaynta nuugista ee peptide, si loo gaaro diiradda hoose iyo waxtarka sare, iyo in la gaaro waxtarka ka hortagga gabowga ka wanaagsan.

Iyada oo laga jawaabayo barta xanuunada warshadaha ee liidata liidata, hydrophilicity sare iyo bioavailability hoose ee macromolecules dhaqameed, wax soo saarka Junas Time Particle via chemistry quantum caawiyay, si toos ah u gaari kartaa epidermis iyo maqaarka maqaarka iyada oo trans-cellular, intercellular iyo follicular ductchannels dhididka. Iyada oo aan waxyeello loo geysan qaab-dhismeedka maqaarka, noolaha badeecada ayaa kordhay 5 jeer, oo ay ku jiraan in ka badan 45% maqaarka maqaarka, iyada oo aan waxyeello u geysan qaab dhismeedka maqaarka.

Farsamada biocatalysis ee supramolecular

Bioenzyme-directed catalysis: dareerayaasha supramolecular waxaa loo isticmaalaa sida substrates si kor loogu qaado dhaqdhaqaaqa enzyme, kor loogu qaado xulashada chiral, oo loo gaaro nadiif sare.

Halsano cagaaran fennel injineernimada: dooro dhirta sifo, kor loogu qaado content ee maaddooyinka firfircoon, formula anhydrous, hagaajinaysaa waxtarka guud

Tignoolajiyada halsano ee micellar-ka roga: baadhista noocyada sifada, saliidda khudradda khamiirsan, saamayn badan, hagaajinta dareenka maqaarka iyo kor u qaadida nuugista

Iyada oo ku saleysan tikniyoolajiyadda hidda-wadaha recombinant, tignoolajiyada hal-tallaabo ee tignoolajiyada hidda-wadaha iyo tignoolajiyada bioenzyme catalytic cufnaanta sare, bakteeriyada hidda-wadaha ayaa loo isticmaalaa sida sideyaal kicinaysa si loo xaqiijiyo wax-soosaarka baaxadda leh ee walxaha firfircoon:

Marka la eego nidaamka dareeraha supramolecular, ensaymku wuxuu muujinayaa waxqabad sare, xulashada iyo xasiloonida, isticmaalka sare ee alaabta ceeriin ee substrate, wasakh yar ee habka wax soo saarka, xaaladaha falcelinta khafiifka ah, waxqabadka amniga sare iyo waxqabadka wax soo saarka.

Tignoolajiyada halsano ee micelle:

Saliidaha dabiiciga ah ee la doortay ee leh sifooyinka Shiinaha lP ayaa si kedis ah loogu talagalay in lagu soo saaro surfactants hoos yimaada ficilka bakteeriyada hidde ahaan loo farsameeyey.lt waxaa la soo ururiyey sida side xirmada anti-micellar si ay u ogaadaan xirmada lidka-micellar ee duubista maaddooyinka firfircoon ee biyo-milmi leh si loo gaaro xaaladaha codsiga qani ah, waayo-aragnimada maqaarka ugu dambeeya, iyo waxtarka la taaban karo, waxtarka, iyo waxtarka.

Tignoolajiyada supramolecular microencapsulation

Astaamaha farsamada: koofiyadaha liposome, sii daynta bartilmaameedka ah ee unugyada maqaarka, sii daynta timaha ee la beegsaday, iyo sii daynta jawaab celinta ee arrimaha caabuqa

Faa'iidooyinka: Nanoization, gaarsiinta saxda ah, sii-deynta joogtada ah ee muddada-dheer, yaraynta xanaaqa, hagaajinta xasilloonida, iyo kor u qaadida sii-deynta

Tusaalooyinka maaddooyinka: astaxanthin, glabridin, vitamin A, peptide copper blue, biotin, ceramide, geedka saliidda muhiimka ah

Tiknoolajiyada supramolecular microencapsulation waxay ku saleysan tahay liposome, emulsion dufan, tignoolajiyada xasilinta dareeraha ionic, tignoolajiyada sii deynta unugyada maqaarka ee bartilmaameedka ah, timaha follicle-ka tignoolajiyada sii deynta, iyo tignoolajiyada sii deynta falcelinta caabuqa Waxa uu leeyahay heerka nuugista transdermal heer sare ah, waqti dheer oo deggenaansho ah iyo degenaansho wanaagsan oo ku taal goobta bartilmaameedka maqaarka. Waxa kale oo ay leedahay qiimo jaban iyo codsiyada waxtarka sare leh ee goobta qurxinta, cuntooyinka shaqada iyo daawooyinka.

Farsamada isku-ururinta ee kala sareynta Peptide

Tilmaamaha farsamada: warshadaha ugu horreeya, nidaaminta la beegsaday ee qaabdhismeedka heerarka badan ee silsiladaha amino acid iyo polypeptides, peptides gaaban oo iskood isu abaabulay, polypeptides supramolecular

Jihada farsamada: Hagaaji amphiphilicity, xooji xasilloonida iyo caabbinta kulaylka, yaraynta sunta iyo walbahaarka difaaca, kor u qaad nuugista, iyo is-dhexgalka

Tusaalooyinka maaddooyinka: carnosine supramolecular, peptide borotiinka khamiirka

Isku-ururinta borotiinka iyo peptides ma aha oo kaliya meel kasta oo ka mid ah nidaamyada nolosha, laakiin sidoo kale waa walax aad u fiican oo jidhka bini'aadamka ah, iyo sidoo kale mid ka mid ah hababka wax ku oolka ah ee loogu talagalay isku-dhafka walxaha nano-nano-bayooloji. Habka isku-ururinta peptide-ku waa nidaam isku-dar ah, iyo "qaab dhismeedka amino acid zipper" waa nooc cusub oo qaab dhismeedka sare ah, kaas oo u sahlaya isku imaatinka kala sareynta ee peptides si loo sameeyo isu geyn la amray.

Nidaaminta jihada cabbirka peptides-gaaban waxaa lagu gaari karaa iyada oo la beddelo hydrophobicity iyo silsiladda dhinac ee haraaga hydrophobic.

Iyada oo ku saleysan Shinehigh Innovation's ProteinDataBank (PDB) xogta gaarka ah, isku dar oo la socda indho-indheyn tijaabo ah oo nidaamsan, dhaqdhaqaaqyada molecular iyo xisaabinta kimistariga quantum si loo falanqeeyo qaab dhismeedka molecules peptide, ka dibna iyaga la mid ah unugyada isku-ururinta sare-sare ee is-ururinta taas oo kor u qaadaysa awoodda molecule si ay isu-urursato. Xaqiiji nidaamka la beegsaday ee peptides. peptide-ka iskiis isku dubariday wuxuu leeyahay amphiphilicity heer sare ah iyo summetry, kaas oo si weyn u wanaajinaya xasilloonida peptide, awoodda transdermal iyo bioavailability.